For more detailed information on the cookies we use, please check our Privacy Policy. We further evaluated the median carboplatin cycle and dose administered to women with and without carboplatin-related hypersensitivity. Abe et al. Clinical features and management of carboplatin-related hypersensitivity reactions in pediatric low-grade glioma. (2010) described the use of cisplatin as an alternative to carboplatin. Int. Expert Opin Drug Saf (2003) 2(6):597607.10.1517/14740338.2.6.597 Paclitaxel plus platinum-based chemotherapy vs. conventional platinum-based chemotherapy in women with relapsed ovarian cancer: the ICON4/AGO-OVAR-2.2 trial. The essential content of the guidelinesin condensed slide format in PDF or PowerPoint. (2005). Challenges in the Development of Intravenous Neurokinin-1 Receptor Antagonists: Results of a Safety and Pharmacokinetics Dose-Finding, Phase1 Study of Intravenous Fosnetupitant. doi: 10.1006/gyno.1994.1098, Keywords: ovarian cancer, chemotherapy, carboplatin, hypersensitivity, risk factor, Citation: Tai Y-H, Tai Y-J, Hsu H-C, Lee S-P, Chen Y-Y, Chiang Y-C, Chen Y-L, Chen C-A and Cheng W-F (2017) Risk Factors of Hypersensitivity to Carboplatin in Patients with Gynecologic Malignancies. Patients with prior drug or food allergies should be closely monitored during carboplatin administration. Several methods have been developed to prevent carboplatin-related hypersensitivity reactions (Libra et al., 2003; Confino-Cohen et al., 2005; Gomez et al., 2009; Greene et al., 2010; Takase et al., 2015; Shah et al., 2016). Epub 2012 May 3. (2010). The .gov means its official. 2022 Mar 30;9(4):26. doi: 10.3390/medicines9040026. Furthermore, patients with carboplatin hypersensitivity had a higher incidence of previous allergic history to other cytotoxic drugs, including gemcitabine, paclitaxel, and doxorubicin, compared to those without (12/75 vs. 30/660, P < 0.001, chi-squared test; Table 7). eCollection 2017. (2005) reported that all carboplatin-associated hypersensitivity reactions occur in patients with prior carboplatin exposure, and Tamiya et al. Prior investigations reported that a history of drug allergies correlates with the incidence of carboplatin-related hypersensitivity reactions (Libra et al., 2003; Sliesoraitis and Chikhale, 2005). Whether desensitization modulates drug allergic and anaphylactic responses facilitating tolerance is currently being investigated. Supportive and Palliative Care | ESMO Management of Infusion Reactions to Systemic Anticancer Therapy: ESMO Clinical Practice Guidelines Published in 2017 - Ann Oncol (2017) 28 (suppl 4): iv100-iv118. The cumulative incidence of carboplatin-related hypersensitivity reactions dramatically increased with >8 cycles or dose >3,500 mg. J Oncol Pract. 8600 Rockville Pike doi: 10.1016/j.ygyno.2016.09.027, Bruchim, I., Goldberg, A., Fishman, A., and Confino-Cohen, R. 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A history of drug or food allergy, the presence of malignant ascites, and the cumulative carboplatin dose are three independent predictive factors of carboplatin hypersensitivity in this survey. Accessibility Fu. Assess for lymphadenopathy, facial or distal extremity swelling (may be signs of drug-induced hypersensitivity syndrome/DRESS). For more detailed information on the cookies we use, please check our Privacy Policy. doi: 10.1111/j.1525-1438.2005.00136.x, Koshiba, H., Hosokawa, K., Kubo, A., Miyagi, Y., Oda, T., Miyagi, Y., et al. The imaging findings follow the American Thoracic Society and European Respiratory Society classification of interstitial pneumonia. 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These recommendations aim to develop guidance to mitigate the negative effects of the COVID-19 pandemic on the diagnosis and treatment of cancer patients. J. Med. An official website of the United States government. 2019 Sep;60(9):2295-2298. doi: 10.1080/10428194.2019.1576871. The incidence of carboplatin-related hypersensitivity was higher in patients with advanced stage disease (P < 0.001, Kruskal-Wallis test), serous and mixed histological types (P = 0.003, Kruskal-Wallis test), malignant ascites (P = 0.009, chi-square test), and history of other drug allergy (P < 0.001, chi-square test). ESMO is a Swiss-registered not-for-profit organisation. Swain: Financial Interests, Personal, Advisory Role: AstraZeneca; Financial Interests, Personal, Advisory Role: Daiichi Sankyo; Financial Interests, Personal, Advisory Role: F. 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Hoffmann-La Roche Ltd. H. Macharia: Non-Financial Interests, Personal, Research Grant, Medical writing support: F. Hoffmann-La Roche Ltd.; Financial Interests, Personal, Full or part-time Employment: F. Hoffman-La Roche. Table 5 reports the incidences of carboplatin hypersensitivity and patient characteristics reported in various investigations, including the present study. Borrs Cuartero J, Farzanegan Miano R, Torres Gorriz MC, Germn Snchez A, Aznar RC, Raducan I, Castell Carrascosa JV, Sanchez Hernandez A, Enrique E. Front Allergy. desensitization; drug allergy; monoclonal antibodies in cancer; platins; taxanes. Cancer. Unauthorized use of these marks is strictly prohibited. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. Front Oncol. Furthermore, Moon et al. J. Gynecol. doi: 10.1016/j.ygyno.2006.10.047, Shah, A. C., Minturn, J. E., Li, Y., Belasco, J. 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Front Oncol. Pharmacol. doi: 10.1200/JCO.2006.06.0913, Polyzos, A., Tsavaris, N., Kosmas, C., Arnaouti, T., Kalahanis, N., Tsigris, C., et al. ESMO Clinical Practice Guidelines Provide your patients with the best care options Supporting your clinical decisions with ESMO's regularly updated Clinical Practice Guidelines and consensus recommendations, developed by the leading experts in our profession. We retrospectively recruited all women with pathologically documented ovarian, fallopian tube, or primary peritoneal cancer treated with single-agent carboplatin or a carboplatin-based combination chemotherapy regimen at National Taiwan University Hospital from January 2006 to December 2013. Such reactions could potentially be reduced or prevented by slowing the infusion rate and using a desensitization protocol involving anti-allergy medications. A prospective single-center study. No use, distribution or reproduction is permitted which does not comply with these terms. A total of 412 (56.1%) patients experienced spontaneous menopause, 295 (40.1%) surgical menopause, and 28 (3.8%) had preserved fertility. Via Ginevra 4, 6900 Lugano - CH Copyright 2023 European Society for Medical Oncology All rights reserved worldwide. It would be worthwhile to design a perspective trial that could randomize patients with carboplatin hypersensitivity to receive an alternative regimen without carboplatin. Genc et al. Carboplatin is among the most commonly used chemotherapeutic agents for ovarian, fallopian tube, and primary peritoneal cancer, as it is active against these types of cancers with usually well-tolerated side effects (Ozols et al., 2003; Parmar et al., 2003; Pfisterer et al., 2006; Pujade-Lauraine et al., 2010). ESMO is a Swiss-registered not-for-profit organisation. Vaccines (Basel). (Markman, 2007) reported that carboplatin-related hypersensitivity reactions rarely occur before cycle 6 or <3,000 mg of drug delivery, with the first episode most commonly occurring with carboplatin administration in the second-line setting, and carboplatin administration beyond 9 cycles or 6,000 mg increasing the risk of severe hypersensitivity reactions, similar to our present observations. 105, 14721479. J. Gynecol. Carboplatin hypersensitivity: does introduction of skin test and desensitization reliably predict and avoid the problem? A three-step method was developed to identify hypersensitivity reactions, including anaphylaxis, in a clinical trial database and could be applied to investigational drugs to improve early detection and monitoring of potential safety concerns, subsequent patient safety management strategies, and potentially programme-wide drug development A framework to rank genomic alterations as targets for cancer precision medicine.ESCAT scores for genomic alterations with actionable drug matches are now being gradually integrated into ESMO tumour-focused Clinical Practice Guidelines. However, basophil activation has been observed in patients with a history of severe carboplatin hypersensitivity reaction (Iwamoto et al., 2014). Leuk Lymphoma. Create your own personalised agenda and browse the complete scientific programme by day, topic, cancer type and track with the ESMO events app. Carboplatin-induced severe hypersensitivity reaction: role of IgE-dependent basophil activation and FcRI. Gemcitabine plus carboplatin compared with carboplatin in patients with platinum-sensitive recurrent ovarian cancer: An intergroup trial of the AGO-OVAR, the NCIC CTG, and the EORTC GCG. Cancer 63, 2126. J. Clin. Epub 2019 Mar 8. reactions to foreign proteins [generally immunoglobulin E (IgE)-mediated allergic responses] or non-immune-mediated reactions [1]. J. Clin. doi: 10.3322/caac.21332, Sliesoraitis, S., and Chikhale, P. J. ESMO Clinical Practice . BRCA1/2 mutation has been reported to correlate with carboplatin hypersensitivity (Altwerger et al., 2017). 105, 8183. Most anticancer treatments carry a risk for infusion reactions which incidence may increase when different agents are administered concomitantly. doi: 10.1111/cas.12538, Kandel, M. J., Loehr, A., Harter, P., Traut, A., Gnauert, K., and du Bois, A. Evaluation of the incidence of carboplatin hypersensitivity in cancer patients. Model of in vitro mouse mast cells activation and desensitization. doi: 10.1111/IGC.0b013e3181a418ff, Greene, D. P., Ferriss, J. S., and Jazaeri, A. PH IV/PH FDC SC is standard of care for HER2-positive BC and usually given with chemotherapy, all of which can trigger anaphylaxis/hypersensitivity. All funding for this site is provided directly by ESMO. The independent sample t-test was used to evaluate how carboplatin cycle and dose correlated with the incidence of hypersensitivity and severe hypersensitivity reactions. Would you like email updates of new search results? 24, 46994707. LUGANO-MADRID, 09 September, 2017 -The preliminary results of a study to be presented at the ESMO 2017 Congress in Madrid (1) show that socio-psychological factors have become more significant for . Authors: S. Rosell, I. Blasco, L. Garca Fabregat, A. Cervantes and K. Jordan The ESMO Expert Consensus Statement series of publications contain recommendations on well-defined, controversial or clinically relevant topics and are produced by 20-40 key experts in the field. The website cannot function properly without these cookies, and you can only disable them by changing your browser preferences. This was the largest series of gynecological malignancies investigated for carboplatin-related hypersensitivity reactions. For more detailed information on the cookies we use, please check our Privacy Policy. Summary format including algorithms, figures andtables for your presentations. 2022 Oct 18;12:994155. doi: 10.3389/fonc.2022.994155. 66, 265267. Statistical analyses were performed using the Statistical Package of Social Studies (SPSS) version 17.0 (SPSS, Inc., Chicago, IL) and SAS software version 9.4 (SAS Inc, NC, USA) for Windows. Hypersensitivity reactions to carboplatin administration are common but not always severe: a 10-year experience. 'Allergy' is a hypersensitivity reaction (HSR) initiated by specic immunolo- gical mechanisms. (2007). Analysis of the pattern of hypersensitivity reactions in patients receiving carboplatin retreatment for recurrent ovarian cancer. Our findings also suggest that a history of drug or food allergies is a predictive factor for carboplatin-related hypersensitivity. Carboplatin and other paltins such as cisplatin and oxaliplatin reactions include classical symptoms of anaphylaxis with cutaneous, respiratory, cardiovascular, and gastrointestinal symptoms. 4-step 4-h carboplatin desensitization protocol for patients with gynecological malignancies showing platinum hypersensitivity: a retrospective study. Deleterious BRCA1/2 mutation is an independent risk factor for carboplatin hypersensitivity reactions. doi: 10.1093/annonc/mdx216. Check the latest publications and updates here to make sure you dont miss anything. Some of these cookies are essential, while others help us improve your experience by providing insights into how the site is being used. We retrieved clinical information, including age, menopausal status, cancer stage, surgical findings, chemotherapeutic treatment history, recurrence status, and survivorship, from the clinical and operative notes and discharge summaries stored in a centralized database. MINIMAL Requirements:Google Chrome 24+,Mozilla Firefox 20+,Internet Explorer 11,Opera 1518,Apple Safari 7,SeaMonkey 2.15-2.23. The results of the trial could answer whether carboplatin hypersensitivity patients have similar chemo-responses in non-platinum regimens without compromising the efficacy of the antineoplastic regimens of these patients. doi: 10.1111/j.1048-891x.2005.14401.x, Takase, N., Matsumoto, K., Onoe, T., Kitao, A., Tanioka, M., Kikukawa, Y., et al. PMC Platinum agent-induced hypersensitivity reactions: data mining of the public version of the FDA adverse event reporting system, AERS. A total of 735 eligible women who underwent treatment for ovarian, fallopian tube, or primary peritoneal cancer were recruited this the study; 75 (10.2%) experienced a total of 215 carboplatin-related hypersensitivity reaction events. doi: 10.2152/jmi.57.163, PubMed Abstract | CrossRef Full Text | Google Scholar, Altwerger, G., Gressel, G. M., English, D. P., Nelson, W. K., Carusillo, N., Silasi, D. A., et al.
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